(Dollars in millions) This in turn follows the recommendations from the Taskforce on Climate-Related Financial Disclosures. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Amgen Inc. (ilgari A pplied M olecular Gen etics Inc.) Amerikaning kop millatli biofarmatsevtika kompaniyasi bolib, shtab-kvartirasi Kaliforniya shtati, Thousand Oaks shahrida joylashgan . Data from the single- and multiple-dose cohorts of this Phase 1 study will be presented at the 20th. This is Amgens third environmental sustainability plan since 2007, and we have seen myriad success stories in our European operations. Amgen Our new commitments expand on our previous achievements and drive Amgens continued leadership on environmental sustainability that will benefit our patients, staff, shareholders and communities.. This follows an overwhelming trend of surpassing our global targets, such as our second generation of environmental targets, set in 2012. Amgen 2010 Environmental Sustainability Report 5 Since 1980, Amgen has been a pioneer, leader, and innovator in medical biotechnology . A Phase 3 study continues to enroll patients with chronic rhinosinusitis with nasal polyps. The Company believes that FCF provides a further measure of the Company's liquidity. (Unaudited), Net cash provided by operating activities, Net cash (used in) provided by investing activities, Net cash provided by (used in) financing activities, Cash and cash equivalents at beginning of period, Cash and cash equivalents at end of period, Amgen Inc. Amgenis one of the 30 companies that comprise the Dow Jones Industrial Average and is also part of the Nasdaq-100 index. Responsibility | Amgen 0000045596 00000 n This prompted analysts from Wolfe Research to strike a note of caution. Taskforce on Climate-Related Financial Disclosures. In August, the Company announced positive top-line results from the DAHLIA study, a randomized, double-blind, active-controlled, two-period crossover Phase 3 study evaluating the efficacy and safety of ABP 959, a biosimilar candidate to SOLIRIS, The primary analysis of a randomized, double-blind, active controlled, Phase 3 study evaluating the efficacy and safety of ABP 938, an investigational biosimilar to EYLEA, A Phase 3 study evaluating the efficacy and safety of ABP 654 compared to STELARA, A Phase 3 study to support an interchangeability designation in the. Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. from a Phase 2 study of rocatinlimab, an anti-OX40 monoclonal antibody, which demonstrated improvement in head and neck atopic dermatitis in patients with moderate to severe disease. Beginning January 1, 2022, the Company's non-GAAP financial measures no longer exclude adjustments for upfront license fees, development milestones and IPR&D expenses of pre-approval programs related to licensing, collaboration and asset acquisition transactions. Reconciliation of Total Revenues Adjusted for Foreign Currency Impact 0000047562 00000 n The Company uses the non-GAAP financial measures set forth in the news release in connection with its own budgeting and financial planning internally to evaluate the performance of the business, including to allocate resources and to evaluate results relative to incentive compensation targets. The adjustments relate primarily to noncash amortization of intangible assets acquired in business acquisitions. Jessica Akopyan, 805-440-5721 (media) A spokesperson told this reporter that the company was not yet ready to discuss our sustainability efforts around our packaging, but did offer a fact sheet about the broader sustainability efforts of the Thousand Oaks, CA-based human therapeutics firm. Amgen reports Further, the Company believes Total Revenues Adjusted for Foreign Currency Impact provides supplementary information on the Company's product sales performance by excluding changes in foreign currency exchange rates between comparative periods. In our Munich headquarters, we have committed to an 80% electric fleet of vehicles, while our Sustainability Plan for Turkey has noted great success in reducing waste, as well as water and energy consumption. Our reporting reflects several international standards and guidelines, including the Global Reporting Initiative, CDP, Sustainability Accounting Standards Board (ESG) Report 2021 . The latest Sustainability Goals for Amgen are outlined in an infographic, explaining how we will use the principles of innovation, efficiency, and renewable energy to push forward. Country-Specific Access Approaches and Collaborations, Transformative Treatment, Approaches and Technology, EU Registration, Evaluation and Authorization of Chemicals. 0000002520 00000 n DeLLpro-300, a Phase 1b study of tarlatamab, continues to enroll patients with de novo or treatment-emergent neuroendocrine prostate cancer. Environmental sustainability makes good business sense--its an important investment in our future.. Copyright 2022 Morningstar, Inc. All rights reserved. 0000006610 00000 n Do you want to link to this References in this release to "non-GAAP" measures, measures presented "on a non-GAAP basis," "free cash flow" (computed by subtracting capital expenditures from operating cash flow) and "total revenues adjusted for foreign currency impact" (computed by converting our current period local currency product sales using the prior period foreign currency exchange rates and comparing that to our current period product sales) refer to non-GAAP financial measures. 0000024889 00000 n The Phase 3 DISCREET study, evaluating Otezla in adult patients with moderate to severe genital psoriasis. The ROCKET Phase 3 program evaluating rocatinlimab in patients with moderate to severe atopic dermatitis was initiated in June. External Website and leave Amgen.eu? Otezla treatment resulted in significant improvements in measures of disease severity at week 16 compared with placebo. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. 0000152989 00000 n The Company uses certain non-GAAP financial measures to enhance an investor's overall understanding of the financial performance and prospects for the future of the Company's ongoing business activities by facilitating comparisons of results of ongoing business operations among current, past and future periods. GAAP to Non-GAAP Reconciliations Added an ESG goal to the Companys goals for our annual incentive plans to focus our entire Company on activities supporting achievement of our 2027 environmental sustainability targets and to strengthen and improve the Companys diversity, inclusion, and belonging efforts. To further our progress, Amgen has included an ESG goal again for 2022. Foreign currency impact was calculated by converting our current period local currency Product sales using the prior period foreign currency exchange rates and comparing that to our current period Product sales. A Phase 3 trial continues to enroll using this combination. In practice, this involves green initiatives such as: Between 2008 and 2020, we have invested $50 million (42.1 million) globally to reach the above mentioned targets. Amgens inaugural report has been confirmed at a C application level by the Global Reporting Initiative. 2020 Amgen Europe GmbH. Dow showcased its REVOLOOP portfolio at PACK EXPO International. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. By continuing to report on our operations throughout Europe and beyond, we can move forward and achieve these targets. Annual Reports | Amgen Inc. Adjustments to the most directly comparable GAAP financial measures and other items are presented on the attached reconciliations. A Phase 1/1b/2 study of AMG 193, a novel small molecule methylthioadenosine (MTA) cooperative protein arginine methyltransferase 5 (PRMT5) molecular glue, continues to enroll patients with advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors. Discover innovative solutions for packaging and processing, automation, sustainability, e-commerce and more. For the quarter, total product sales were recorded at $6.2bn, a 1% drop from $6.3bn in Q3 2021. Amgen's Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. Amgen Inc. (AMGN The fact sheet says, As a global leader in human therapeutics, Amgen is committed to environmentally responsible operations, using natural resources wisely, and considering its overall impact on the environment.. We also ensure all medicines are regulated by the European Medicines Agency, and comply with standards set by the: We regularly conduct staff engagement surveys and run round-table discussions to promote a sustainability-first culture, recording our teams thoughts on our progress so far. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. Amgen has reported a 1% decline in total revenues to $6.65bn in the third quarter (Q3) of 2022 as against $6.7bn in the year-ago quarter. 0000056045 00000 n AMGEN Amgen publishes initial sustainability report | Packaging World Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. Beginning January 1, 2022, following industry guidance from the U.S. Securities and Exchange Commission, the Company no longer excludes adjustments for upfront license fees, development milestones and IPR&D expenses of pre-approval programs related to licensing, collaboration and asset acquisition transactions from its non-GAAP financial measures. Amgen Amgen 2014 Environmental Sustainability Highlights Otezla treatment showed a clinically meaningful and statistically significant improvement in genital psoriasis, including improvements in skin clearance, itch, and quality of life at week 16 compared with placebo. Where we want to be: 100% carbon neutral by 2027. Transparency is how we protect the integrity of our work and keep empowering investors to achieve their goals and dreams. Maintaining independence and editorial freedom is essential to our mission of empowering investor success. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. Amgen A Phase 1 dose-escalation study of AMG 340, a lower T-cell affinity BiTE molecule targeting prostate-specific membrane antigen (PSMA), continues to enroll patients with mCRPC. In just the past six months,Amgenhas been named to Newsweek magazines list of Americas Most Responsible Companies for the third consecutive year;JUST Capitalslist of Americas Most JUST Companies for the fifth consecutive year; Barrons list of Americas Most Sustainable Companies for the second consecutive year; and theHuman Rights Campaign Foundationslist of Best Places to Work for LGBTQ+ Equality for the sixth consecutive year. Dose expansion is ongoing in treatment-nave patients using lower-dose LUMAKRAS lead-in followed by combination of LUMAKRAS with pembrolizumab. 0000022272 00000 n Amgen Inc. THOUSAND OAKS, Calif., Feb. 7, 2022 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced financial results for the fourth quarter and full year 2021 versus comparable periods in 2020. 0000027659 00000 n The company recycles 75% of the wastewater generated at its operations in Puerto Rico. 0000150163 00000 n Refer to Non-GAAP Financial Measures below for further discussion. 1996-2022 Amgen Inc. All Rights Reserved. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Amgen Inc., a biotechnology medicines company, discovers, develops, manufactures, and markets human therapeutics based on advances in cellular and molecular biology for grievous illnesses primarily in the United States, Europe, and Canada. The Company believes that its presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. FORTITUDE-201, a Phase 1b study of bemarituzumab monotherapy and in combination with standard of care therapy continues to enroll patients with squamous NSCLC with FGFR2b overexpression. Amgen 2010 Environmental Sustainability Report In August, data were presented demonstrating that. 0000178397 00000 n All Rights Reserved. JW Winco adds the GN 814 stainless steel lockable indexing plungers designed to protect against unauthorized or accidental operation. Amgen is setting goals in order to improve our focus. For the three and nine months ended September 30, 2021, the adjustments related primarily to the change in fair values of contingent consideration liabilities. In tandem, we are also following guidance from the UNs 17 Sustainable Development Goals and the Carbon Disclosure Project. FORTITUDE-101, a Phase 3 study of bemarituzumab a fibroblast growth factor receptor 2b (FGFR2b) targeting monoclonal antibody, plus chemotherapy, versus placebo plus chemotherapy in first-line gastric cancer with FGFR2b overexpression continues to enroll patients. 0000001867 00000 n amgen.com, highlights how the company is successfully implementing an Wed like to share more about how we work and what drives our day-to-day business. We have launched a Responsibility section on Amgen.com as part of our broader commitment to communicating our non-financial performance. Where we want to be: An additional 75% less waste generated by 2027. LETTER FROM BOB For purposes of comparability, the non-GAAP financial results for the third quarter of 2021 have been updated to reflect this change. Amgen Inc., a biotechnology medicines company, discovers, develops, manufactures, and markets human therapeutics based on advances in cellular and molecular biology for grievous illnesses demonstrating that rocatinlimab provides durable normalization of atopic dermatitis inflammation-related gene expression in skin biopsies from atopic dermatitis patients.
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